Figure 2. Nanodisc composition and environment dictates the extent of modulation on hIAPP aggregation.

By changing the concentration of negatively charged DMPG lipids in the nanodisc (25% in ND2% and 50% in ND3), the pH of the surrounding buffer (7.4 with 20 mM PO₄ or 5.3 with 30 mM acetate) and the solution temperature, a wide range of kinetic behaviors can be observed for hIAPP.