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. 2017 Nov 20;6:e29303. doi: 10.7554/eLife.29303

Figure 6. MYPT1 cross-regulates Cyclin A/Cdk1-dependent priming and self-priming of Plk1 substrates during mitosis.

Figure 6.

Cyclin/Cdk1 has an established role in catalyzing the priming phosphorylation of substrates to promote Plk1 binding as depicted for hypothetical substrate ‘A’. MYPT1 is a specific substrate shown to be sensitive to Cyclin A/Cdk1 catalyzed priming phosphorylation for interaction with Plk1. In turn, MYPT1 recruits PP1 to dampen Plk1 which reduces the level of self-priming for hypothetical substrate ‘B’.