Table 2. Association between the quantity of each immune subset and progression-free survival.
Factors | Hazard ratio* | 95% CI | p-value | |
---|---|---|---|---|
Suppressor cells | Granulocytic MDSCs | 2.61 | 1.20–5.68 | 0.01 |
Monocytic MDSCs | 0.88 | 0.43–1.82 | 0.73 | |
CD4+FOXP3+ | 0.64 | 0.32–1.26 | 0.19 | |
Naïve Tregs | 1.00 | 0.51–1.97 | 0.99 | |
Effector Tregs | 1.01 | 0.51–2.00 | 0.98 | |
Effector cells | CD3+ | 0.79 | 0.39–1.57 | 0.49 |
CD4+ | 1.03 | 0.52–2.04 | 0.93 | |
Naïve | 0.78 | 0.39–1.56 | 0.48 | |
Central memory | 1.56 | 0.79–3.07 | 0.20 | |
Effector memory | 0.87 | 0.44–1.72 | 0.69 | |
Terminally differentiated effector | 0.62 | 0.31–1.23 | 0.17 | |
Granzyme B+ | 1.14 | 0.57–2.27 | 0.71 | |
Perforin+ | 0.99 | 0.50–1.96 | 0.99 | |
Ki67+ | 1.11 | 0.56–2.18 | 0.77 | |
CD8+ | 0.80 | 0.40–1.59 | 0.52 | |
Naïve | 1.20 | 0.61–2.36 | 0.61 | |
Central memory | 0.74 | 0.38–1.46 | 0.39 | |
Effector memory | 0.65 | 0.33–1.28 | 0.21 | |
Terminally differentiated effector | 0.65 | 0.33–1.29 | 0.21 | |
Granzyme B+ | 0.75 | 0.38–1.49 | 0.41 | |
Perforin+ | 0.85 | 0.43–1.68 | 0.65 | |
Ki67+ | 0.98 | 0.50–1.95 | 0.96 | |
Natural killer | 0.78 | 0.39–1.53 | 0.47 | |
Antigen presenting cells | Myeloid dendritic cells | 0.98 | 0.47–2.04 | 0.96 |
Plasmacytoid dendritic cells | 0.83 | 0.40–1.71 | 0.61 |
MDSCs, myeloid-derived suppressor cells; Tregs, regulatory T cells.
* Low group (< median) in each immune subset was used as a reference.