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. 2017 Jul 27;8(56):95135–95151. doi: 10.18632/oncotarget.19619

Figure 7. Early and prolonged CMKLR1 inhibition with α-NETA impairs tumor growth in vivo.

Figure 7

Kaplan-Meier survival plots of nude mice (n=11 in control group and in pre-treatment group, n=10 in treatment group) injected daily s.c. with 20mg/kg α-NETA after the tumor reached 0.15ml (treatment group), 10mg/kg α-NETA from the day after tumor cell injection and 20mg/kg when the tumor reached 0.15ml (pre-treatment group) or 10% Captisol® (control group). Survival, defined as time needed for the animals to grow a macroscopic tumor (volume >1.5ml), was significantly prolonged in the pre-treatment group (log rank test P=0.015, control vs. pre-treatment P= 0.019 and control vs. treatment P=0.51).