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. 2017 Jun 29;8(56):95176–95191. doi: 10.18632/oncotarget.18820

Figure 6. Functional prediction of microbial genes associated with PC using PICRUSt.

Figure 6

(A) The 23 predicted microbial functions including Leucine biosynthesis, Isoprenoid biosynthesis non mevalonate pathway and LPS biosynthesis were significantly enriched, while 13 functions including Type V ATPase in prokaryotes, Spermidine putrescine transport system and Histidine biosynthesis were remarkably reduced in PC patients versus HC, shown by LDA score (log 10). (B) The 6 predicted microbial functions including Inosine monophosphate biosynthesis, C5 isoprenoid biosynthesis non mevalonate pathway and Tyrosine biosynthesis were significantly increased, whereas 5 functions including Threonine biosynthesis, Sorbitol mannitol transport system and Shikimate pathway of phosphoenolpyruvate were decreased in PCH-unO versus PCH-O patients, shown by LDA score (log 10). PICRUSt: Phylogenetic Investigation of Communities by Reconstruction of Unobserved States; LDA, linear discriminant analysis; HC, healthy controls; PC, pancreatic carcinoma; PCH, PC (head); PCH-O, PCH with obstruction of common bile duct; PCH-unO, PCH with unobstruction of common bile duct.