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. 2017 Jul 12;8(56):95206–95222. doi: 10.18632/oncotarget.19199

Figure 3. The combination of teriflunomide and PF477736 results in increased antiproliferative effect in transformed mouse embryonic fibroblasts.

Figure 3

Primary, immortalised or transformed mouse embryonic fibroblasts were exposed for 24 hours to increasing concentrations of teriflunomide ± transformed MEF IC10 PF477736 (0.7 μM) (which was added 30 minutes after the beginning of exposure to TFN) (A) or IPP-A017-A04 ± transformed MEF IC10 PF477736 (B), and grown in drug-free medium for three doubling times. Mean ± SD, n = 3 independent experiments. *p < 0.05, **p < 0.01 as determined by two-tailed unpaired t-test.