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. 2017 Jul 12;8(56):95206–95222. doi: 10.18632/oncotarget.19199

Figure 8. The combination of teriflunomide and PF477736 induces H2AX phosphorylation on serine 139 (γH2AX) in SUM159 triple negative breast cancer cell line.

Figure 8

(A) Immunofluorescence of DNA (blue) and γH2AX (green) in SUM159 cells that were exposed to either 25 μM TFN, IC10 PF477736 (2.5 μM) or the combination of these compounds. Scale bar, 20 μm (B) Western blotting analysis of H2AX phosphorylation on serine 139 (γH2AX) in cell lysates prepared 2, 6 and 48 hours after the beginning of the exposure to either compound, their combination or 0.1 μM positive control camptothecin (CPT).