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. 2017 Aug 24;8(56):95361–95376. doi: 10.18632/oncotarget.20545

Figure 6. Glutamine decrease and BCAAs increase are linked to PDAC progression in KC mice.

Figure 6

(A) C57BL/6 mice were injected orthotopically into the pancreas with K8484 cells. Total blood glutamine concentration was evaluated using an HPLC instrument at the indicated time points. Results are represented for each mouse (10 mice/each time point) and mean±SEM are indicated. (B-F) Analysis of total glutamine (B), valine (C), isoleucine (D), leucine (E) and total branched-chain amino acids concentration (F) in KC mice (3-10 mice/group) at the indicated time points compared to control group (mice <2 months old). * P <.05; ** P <.01; *** P <.001 values at days 15 and 30 significantly different from those measured at day 0, and KC and WT mice older than 2 months compared to mice less than 2 months old.