Figure 6. EV20-Sap shows a potent in vivo antitumor activity in a model of melanoma experimental metastasis.

(A) Schematic representation of experimental lung metastasis assay. (B) Number (left) and size (right) of lung metastatic lesions evaluated at the end of the experiment in control (n=6), EV20-Sap (n=6) and free Saporin (n=6) treated animals. Error bars represent SD. p values were determined by Student's t test. ^**p<0.01. (C) Representative images of haematoxylin and eosin (H&E) of lung sections of control and treated groups (upper panel) and corresponding immunohistochemical staining of HER-3 on metastatic lesions (lower panel).