Table 1. HER-3 expression in human melanoma metastases.

Metastatic site	No. Positive/Total	Score*
Lymph node (synchronous)	27/38 (71%)	17H; 7T; 3(1+); 11 Neg
Lymph node (metachronous)	13/17 (76%)	4H; 8T; 1+; 4 Neg
Other	10/13 (77%)	4H; 4T 2(1+); 3 Neg
(Subcutaneous, ovary, lung, adrenal, brain, muscle)

^* Lesions were scored as “negative” when no cellular or interstitial component was stained on a wide range of primary antibody concentrations (5-20 μg/ml) or “Positive” which were in turn classified as “trace (T)” when an homogenous weak stain was detected, or “1+” when an homogenous well defined stain outlined the tumor cells population, “heterogeneous(H)” when tumor cells within a lesion displayed either trace, or 1+ stain, or negative scattered areas which did not exceeded 10% of the whole available sample.