Table 2. GO enrichment analysis, cellular component and Ingenuity Pathway Analysis, diseases and functions for low and high abundance proteins conveyed by plasma-derived extracellular vesicles from lung adenocarcinoma cases and disease-free controls.

A. GO enrichment analysis, cellular component: low abundance (560)
Pathway ID	Pathway description	Observed gene count	False discovery rate
GO.0070062	extracellular exosome	185	3.16E-34
GO.0044421	extracellular region part	210	7.91E-31
GO.0031988	membrane-bounded vesicle	201	1.69E-30
GO.0031982	vesicle	202	3.16E-29
GO.0005576	extracellular region	221	1.97E-25

B. Pathway analysis, diseases and functions: low abundance case:control ratio >1.3-fold (203)
Diseases and Bio Functions, Categories	p-Value range	# Molecules
Diseases
Cancer	2.9E-03 – 1.3E-11	192
Organismal Injury and Abnormalities	2.9E-03 – 1.3E-11	194
Respiratory Disease	2.9E-03 – 1.3E-11	66
Bio Functions
Cell Death and Survival	2.7E-03 – 2.1E-10	90
Cellular Movement	2.9E-03 – 1.4E-09	52
Carbohydrate Metabolism	1.8E-03 – 2.2E-07	39

C. GO enrichment analysis, cellular component: high abundance (80)
Pathway ID	Pathway description	Observed gene count	False discovery rate
GO.0072562	blood microparticle	43	1.38E-78
GO.0005615	extracellular space	57	1.40E-51
GO.0070062	extracellular exosome	63	4.04E-41
GO.0044421	extracellular region part	64	1.97E-35
GO.0005576	extracellular region	64	6.03E-31

D. Pathway analysis, diseases and functions: high abundance (80)
Diseases and Bio Functions, Categories	p-Value range	# Molecules
Diseases
Metabolic Disease	1.1E-04 – 3.7E-23	43
Neurological Disease	1.4E-04 – 1.1E-20	43
Gastrointestinal Disease	1.1E-04 – 6.1E-16	71
Bio Functions
Lipid Metabolism	1.3E-04 – 5.4E-15	38
Molecular Transport	1.4E-04 – 5.4E-15	47