Table 1. MicroRNA's expression and their roles in associative learning.
Name of microRNA | MicroRNA expression in CR-formation versus control | Predicted target genes | Functions of target genes |
---|---|---|---|
Piriform cortex | |||
mmu-miR-342-5p | ↓↓ | Neto1 Elfn1 Fgfr2 Gria1 Grin1 Lrrtm2 Nlgn3 |
|
Gria1 | |||
Elfn1 | Excitatory synapses | ||
mmu-miR-324-5p | ↑↑ | Grin1Lrrtm2Nlgn3Fgfr2 | |
mmu-miR-5128 | ↑ | Fgfr2 | |
mmu-miR-150-5p | ↑ | Csnk1dNlgn2 | |
mmu-miR-3072-3p | ↑ | Slc32a1 | |
mmu-miR-150-5p | ↑ | Nlgn2 | |
mmu-miR-324-5p | ↑↑ | Slc32a1Nrxn1 | Inhibitory synapses |
mmu-miR-23b-3p | ↑↑ | Nrxn1 | |
mmu-miR-133a-3p | ↑↑ | Iqsec3 | |
mmu-miR-874-5p | ↑↑ | Ywhaq | |
mmu-miR-345-5p | ↑ | Gabra4Rgma | synapse formation or neuron branching |
mmu-miR-149-3p | ↑↑ | Rgma | |
mmu-miR-324-5p | ↑↑ | Ttbk1 | |
mmu-miR-133a-3p | ↑↑ | Dyrk2 | Axon guidance and cytoskeleton |
mmu-miR-3072-3p | ↑ | Mark2 | |
mmu-miR-874-5p | ↑↑ | Gmip | |
mmu-miR-345-5p | ↑ | Rgma | Spines and dendrites |
mmu-miR-324-5p | ↑↑ | Ttbk1 | |
mmu-miR-149-5p | ↑↑ | RhoaRgma | |
mmu-miR-149-3p | ↑↑ | Rhoa | |
mmu-miR-3072-3p | ↑ | Wnk2 | Channels |
mmu-miR-149-5p | ↑↑ | ↑↑ | |
mmu-miR-150-5p | ↑ | Csnk1d | Neurite outgrowth |
mmu-miR-133a-3p | ↑↑ | Dyrk2 | |
mmu-miR-149-3p | ↑↑ | Rgma | |
mmu-miR-133a-3p | ↑↑ | Dyrk2 | Neuron proliferation and differentiation |
↑: log2(CR-formation/Control) <1; ↑↑: 1≦log2(CR-formation/Naïve control) < 2; ↑↑↑: log2(CR-formation/Control) ≧2.