Table 3. Prognostic factors for overall survival in the study population: bivariate analyses.
| Variable | Description | HR [95% CI] | p value |
|---|---|---|---|
| Age ≥ 65 | 103(64.0%) | 0.76 [0.55;1.07] | 0.114 |
| BMI ≥25 kg/m2 | 107(68.1%) | 0.63 [0.44;0.91] | 0.014 |
| Ascites | 27(16.77%) | 0.83 [0.54;1.26] | 0.380 |
| Cirrhosis | 140(87.0%) | 1.22 [0.75;1.99] | 0.412 |
| Number of lesions≥3 | 113(70.2%) | 1.30 [0.90;1.86] | 0.151 |
| Macroscopic vascular invasion | 72(44.7%) | 1.74 [1.26;2.42] | 0.001 |
| Lymph node involvement | 53(32.9%) | 1.36 [0.96;1.91] | 0.080 |
| Distant metastasis | 48(24.2%) | 0.90 [0.62;1.29] | 0.550 |
| Child Pugh score B (vs A) | 39(24.2%) | 2.40 [1.75;3.47] | <.001 |
| Previous locoregional treatment | 95(59.0%) | 0.75 [0.54;1.04] | 0.084 |
| WBC >10 x109/L | 14(8.70%) | 1.56 [0.88;2.76] | 0.130 |
| Platelet count ≥150 G/L | 88(55%) | 0.98 [0.70;1.36] | 0.882 |
| PT < 70% | 27(18%) | 1.85 [1.20;2.84] | 0.005 |
| Total bilirubin >17 μmol/L | 79(49.1%) | 1.61 [1.16;2.22] | 0.004 |
| Albumin <3.5 g/dL | 68(43.0%) | 1.62 [1.16;2.26] | 0.004 |
| ALT >40 U/L | 101(63.1%) | 1.63 [1.16;2.30] | 0.006 |
| AST >38 U/L | 133(82.6%) | 2.57 [1.63;4.03] | <.001 |
| AFP ≥400 ng/mL | 60(37.3%) | 1.43 [1.03;2.00] | 0.033 |
| ALP >120 U/L | 129(81.1%) | 2.54 [1.64;3.95] | <.001 |
| GGT >250 U/L | 81(51.9%) | 1.67 [1.19;2.34] | .0027 |
| NLR≥4 | 78(48.5%) | 1.74 [1.25;2.40] | 0.001 |
| dNLR ≥3 | 45(28.1%) | 2.28 [1.59;3.28] | <0.001 |
| PLR≥200 | 54(33.8%) | 1.54 [1.09;2.18] | 0.014 |
| LMR<3 | 112(69.6%) | 1.45 [1.02;2.06] | 0.037 |
| PNI<45 | 106(67.1%) | 2.01 [1.40;2.88] | <.001 |
| SII≥600 (× 109) | 84(66.9%) | 1.54 [1.11;2.13] | 0.010 |
Abbreviations: WBC= white blood cell count; PT= prothrombin time; ALT= alanine aminotransferase; AST = aspartate aminotransferase; AFp= alpha-fetoprotein; ALp= alkaline phosphatase; GGT= gamma-glutamyltranspeptidase; NLR= neutrophil-to-lymphocyte ratio; dNLR= derived neutrophil-to-lymphocyte ratio; PLR= platelet-to-lymphocyte ratio; LMR= lymphocyte-to-monocyte ratio; PNI= prognostic nutritional index; SII = systemic-immune inflammation index
The WBC, PT, PLT, ALT, AST, ALP cut-offs were defined according to the clinical significance of their normal upper limit. The age, albumin and AFP cut-offs were chosen according to previous published thresholds with proven prognostic value. The GGT, NLR, dNLR, PLR, LMR, PNI, and SII cut-off levels corresponded to the value that maximized the probability in the bivariate Cox model.