Table 3. IC₅₀ values^a (μM) of compounds 1-8 against carcinoma and normal tissue cell lines.

	Carcinoma cell lines			Normal tissue cell lines
No.	U2OS	SW620	ES-2	Lo2	Vero
1	111.40±1.29	45.02±1.23	55.50±1.08	150.30±1.09	>300
2	54.24±1.10	103.80±1.07	76.78±1.09	>300	260.40±1.16
3	73.19±1.24	70.93±1.08	90.58±1.12	>300	>300
4	66.44±1.11	56.46±1.15	64.24±1.28	279.10±2.17	>300
5	64.40±1.08	61.80±±1.06	80.13±3.56	>300	>300
6	57.79±1.07	53.72±1.06	37.26±3.56	>300	>300
7	96.30±1.13	100.70±1.07	74.45±1.17	>300	>300
8	95.36±1.05	55.21±1.16	60.88±1.34	>300	>300
(S)-Cb	32.28±1.28	17.50±1.11	9.09±1.06	26.01±1.20	16.69±1.15

^a IC₅₀ values of the isolated compounds were obtained from the mean OD values of the triplicate tests versus the drug concentration curves.

^b (S)-C represents (S)-crizotinib, which was used as positive control.