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. 2017 Oct 6;8(56):95931–95944. doi: 10.18632/oncotarget.21562

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Copyright: © 2017 Li et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Pearson correlation coefficients between the 44 metabolites were calculated on the basis of the average normalized quantities of metabolites. Highly correlated metabolites with r> 0.8 were connected with solid lines, which metabolite with r< -0.8 were connected with dotted lines in the network. Orange plots indicated up-regulated metabolites and green plots indicated down-regulated metabolites in PV.