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. 2017 Oct 6;8(56):95999–96012. doi: 10.18632/oncotarget.21625

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Copyright: © 2017 Al-Qathama et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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(A) Caspase-3/7 activity in human melanoma A375 cells treated with GI₅₀ of Diphyllin and derivatives at different incubation periods (24, 48 and 72h). Pac= paclitaxel (positive control). (B) Densitometric evaluation of the expression levels of Bax/Bcl-2 proteins normalised to β-actin and changes in Bax/Bcl-2 ratio, CPT= camptothecin (positive control). (C) Immunoblot images of their expression in human melanoma A375 cells after 48h treatment with GI₅₀ of Justicidin B, Diphyllin methyl ether (DiME), Diphyllin apioside (DiA), and Diphyllin acetylapioside (DiAA). Data are presented as the mean ±SD (n=3).