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. 2017 Oct 9;8(56):96089–96102. doi: 10.18632/oncotarget.21716

Figure 4. D561-0775 significantly induced apoptosis in H1975.

Figure 4

(A) Flow cytometric analysis of the apoptosis level after D561-0775 treatment for 48 h. (B) Statistical analysis result of apoptosis data. (C) PARP was cleaved by D561-0775, while p-AKT, Bcl-2 were decreased by treating with D561-0775 for 48 h. (D) Statistical analysis of the densitometry of the signals of cleaved PARP, p-AKT, AKT, Bcl-2. (E) Photomicrographs of colony formation assay data after treatment with D561-0775 at different doses (0, 5, 10, 20 μM). (F) Statistical analysis of colony formation assay. All data was presented as mean ± SD (n= 3, * p < 0.05, ** p < 0.01, *** p < 0.001). All western blot images were cropped from full-length blots.