Figure 3. Processing of proglucagon and glucagon-like peptides in the pancreas and intestine.

Detection of immunoreactive forms of GLP-1 in extracts from rat pancreas (A) and intestine (B) as adapted from ref. 16. Characterization of proglucagon-derived peptide immunoreactivity secreted from perfused pig pancreas and intestine (C) using peptide-specific antisera reveal tissue-specific posttranslational processing of the PGDPs, as outlined in ref. 17.