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. 2017 Nov 6;127(12):4437–4448. doi: 10.1172/JCI96185

Figure 7. Comparison of RAVV pathology and antigen in representative tissues of rhesus monkeys either treated or not with NP-718m–LNP.

Figure 7

(A) Spleen: diffuse lymphoid depletion of the white pulp and fibrin deposition in the red pulp in a RAVV-infected control animal. (C) Spleen: diffuse cytoplasmic immunolabeling of dendriform mononuclear cells in the red and white pulp of a RAVV-infected control animal. No overt lesion (E) or immunolabeling (G) was observed in spleen of an NP-718m–LNP–treated animal. (B) Liver: multifocal necrotizing hepatitis, sinusoidal leukocytosis, and eosinophilic cytoplasmic inclusion bodies in a RAVV-infected control animal. (D) Liver: diffuse cytoplasmic immunolabeling (brown color) of sinusoidal lining cells, kupffer cells, and hepatocytes. No overt lesion (F) or immunolabeling (H) was observed in the liver of a NP-718m–LNP–treated animal. All representative images were taken (original magnification, ×20) from the NP-718m-11–treated animal or an untreated control animal 6 days p.i.