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. 2013 Dec;183(6):1945–1959. doi: 10.1016/j.ajpath.2013.08.026

Figure 4.

Figure 4

Microarray analysis of PKCλ/ι- and PKCζ-deficient podocytes. Diagram shows the total number of regulated genes in cells deficient for PKCλ/ι or PKCζ and the number of more than twofold up-regulated ↑ or more than twofold down-regulated ↓ genes (in brackets) and the intersection of the two compared conditions. The top 30 genes up-regulated or down-regulated in PKCλ/ι- but not in PKCζ-deficient cells are illustrated in heat maps. Intensity of regulation is shown as low expression (blue) or high expression (pink). Genes are clustered according to similar intensity using the Software Multi Experiment Viewer at the left side of each heat map. For each genotype, two different cell lines were analyzed in the microarray.