Table 3.
Predictive Biomarkers for CDK4/6 Inhibitors
| Author | Agent | Setting (n) | Biomarker | Outcome |
|---|---|---|---|---|
| Wainberg58 | PD-0332991 | Gastric cancer cell lines (17) | Cyclin D1 amplification | ↑Sensitivity |
| Cyclin E | ↑Resistance | |||
| Colon cancer cell lines (27) | p16 loss | ↑Resistance | ||
| p21 gain | ↑Resistance | |||
| Konecny78 | PD-0332991 | Ovarian cancer cell lines (40) | p16 low expression | ↑Sensitivity |
| Finn79 | PD-0332991 | Breast cancer cell line (47) | p16 decrease | ↑Sensitivity |
| Cyclin D1 increase | ↑Sensitivity | |||
| pRb | ↑Sensitivity | |||
| von Euw77 | PD-0332991 | Melanoma cell lines | Hedgehog pathway activation | ↑Resistance |
CDK, cyclin-dependent kinase; pRb, phosphorylated retinoblastoma.