Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 29;7:16585. doi: 10.1038/s41598-017-16828-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Interference of the presence of NAbs positive autologous serum in STAT1 activation and cross-reactivity. Expression of pSTAT1 quantified by phosphoflow in monocytes, CD4+ and CD8+ T lymphocytes from MS patients after stimulation with 1000 IU/mL IFNβ (Avonex, Betaferon or Rebif), in presence of autologous serum with NAbs generated against IFNβ1a (Rebif) received as treatment, and in presence of B18R inhibitor. The activation of pSTAT1 reached after IFNß stimulation decreased significantly in presence of NAbs positive autologous serum compared to the activation without serum in T cells and monocytes. NAbs generated against Rebif, were able to cross-react and to decrease significantly pSTAT1 expression achieved with the other two IFNβ molecules in the three subpopulation analyzed. Data are shown as MFI and percentage of cells expressing pSTAT1. Significant p values are shown with asterisk, *p ≤ 0.05; **p ≤ 0.01.