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. 2017 Nov 29;7:16547. doi: 10.1038/s41598-017-16702-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Intrathecal IL-27, and IL-35 gene therapy protects EAE mice from tissue damage. Neuropathological analysis of demyelination (A), axonal loss (B), infiltrates (C), and CD3⁺ T cells (D). The protective effect of IL-27HA gene therapy is associated to a significant decrease of demyelination (E), axonal damage (F), inflammatory infiltrates (G), and number of infiltrating CD3⁺ T cells (H) (mean ± sd). IL-35HA gene therapy promoted a significant decrease of inflammatory infiltrates (G). *p < 0.05; (1 way anova; E–H n = 5/group). We show here one representative out of three independent experiments.