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. 2017 Nov 29;7:16547. doi: 10.1038/s41598-017-16702-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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IL-27 gene therapy decreases CNS infiltrating CD4⁺ T cells expressing gm-csf and IL-17. FACS analysis of CNS-infiltrating CD45⁺CD4⁺ T cells isolated from gene therapy-treated EAE mice (A,F). Intracellular staining for IFNγ (B), GM-CSF (C), IL-17 (D), or GM-CSF/IL-17 (E). IL-27, but not IL-35, significantly decreased GM-CSF and IL-17 expression in CD4⁺ T cells (H,I). Gating strategy is shown in Supplementary Figure. 6. *p < 0.05 (1 way Anova, n = 6/group).