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. 2017 Nov 29;7:16577. doi: 10.1038/s41598-017-16441-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ARF dysregulates multiple signaling pathways in vivo in genetic engineering mouse model of prostate cancer. Pten/Trp53 knockout mice were used for further knockout of p19^Arf(+/–). The prostate tissue samples were collected for microarray analysis. Gene expression profiles were compared within the two groups and re-analyzed for pathways using DAVID online tools. (A) Pathways including Hippo and Wnt were found in the whole profiles analysis. The differential expressed genes were marked as red color of star shape. (B) and (C) Gene expression of Hippo and Wnt pathways^24,25, respectively. The blue color indicates the downregulation and pink color indicates the upregulation.