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. 2017 Nov 29;7:16577. doi: 10.1038/s41598-017-16441-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dysregulated phosphorylation, nuclear localization of YAP and associated F-actin formation by C-dots which stimulate ARF. (A) C-dots increases ARF expression at 0.2 mg/ml in PC3 cells. (B) 0.1 mg/ml C-dots decreases cell growth in an ARF-dependent manner in PC3 cells. (C) 0.2 mg/ml C-dots decreases YAP nuclear localization and the interactions between ARF and YAP in PC3 cells. (D) Time lapse of C-dots localization in nucleus in MCF7 cells. (E) 0.2 mg/ml C-dots decreases F-actin in lung cancer A549 cells. (F) 0.2 mg/ml C-dots decreases cell migration in PC3 cells. Scale bars, 20 µm.