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. 2017 Oct 25;9(11):312. doi: 10.3390/v9110312

Figure 1.

Figure 1

(A) Schematic diagram of the construction of recombinant plasmids. (a) The constitutive cell surface expression plasmid pPG-T7g10-PPT, (b) recombinant plasmid pPG-T7g10-PPT-COE containing core neutralizing epitope (COE), (c) recombinant plasmid pPG-T7g10-PPT-COE-DCpep containing the fusion gene COE-DC-targeting peptide (DCpep); (B) Details of the immunization schedule for recombinant lactic acid bacteria and sampling post-immunization. Red arrows indicate the time points of primary immunization and booster immunization; black arrow (above the line) indicate the time point of intestinal mucus collection, and black arrows (below the line) indicate the time points of serum and genital tract secretions collection.