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. 2017 Oct 30;9(11):320. doi: 10.3390/v9110320

Figure 2.

Figure 2

Survival by day of treatment initiation in the intranasal inoculation mousepox model. Data were pooled across studies and include different mouse strains, viral inoculum levels, and BCV dosage regimens. Data included for Studies CMX001-SLU-005, -006, -007, -008, -009, -011, -012, -013, -014, and CMX001-VIR-102 (initial BCV doses of 10 mg/kg to 30 mg/kg or placebo, single ± maintenance doses, treatment initiation Day 0 to Day 7, A Strain (A/NCR, A/J), SKH-1, C57Bl/6, and BALB/c mice). Individual studies included either male or female mice. All SKH-1, C57Bl/6, and BALB/c mice represented in the figure were female (N = 132, 110, and 55, respectively). A Strain mice included both males and females (N = 266 and 179, respectively). The numbers above the bars indicate the percentage survival. The number of animals for each treatment initiation day: Day 0 = 35, Day 1 = 20, Day 2 = 30, Day 3 = 75, Day 4 = 115, Day 5 = 144, Day 6 = 168, Day 7 = 44, PBO = 111. * Two-sided Fisher’s exact test, p < 0.0001 vs. placebo. No adjustments were made for multiple comparisons. These results have been previously published [17,18,19], with the exception of the BALB/c results (Study CMX001-VIR-102).