Figure 7.

Structural conservation among the rodent protoparvoviruses. 2D projection roadmap of the LuIII capsid surface showing the viral asymmetric unit (black triangle). Colors are as indicated in the panel at the bottom. For VP2 positions in cyan, the LuIII Cα backbone deviates from MVM and H-1PV by more than 2.0 Å. Within the “shared” positions, the Cα distances between superposed VP2 structures vary by less 2.0 Å (see blue for MVM/LuIII or orange for H-1PV/LuIII). Residues in white are structurally conserved among all three viruses. The sialic acid binding site identified for MVM and predicted for H-1PV is delineated in purple. Important surface exposed residues within VR5 and VR4b are delineated in black. Icosahedral axes are indicated by the filled oval (2-fold), triangle (3-fold), and pentagon (5-fold).