Table 3.

Superposition Comparison of LuIII to other Protoparvoviruses.

VR	Residue Range	RMSD (Å)
LuIII	LuIII VP2	MVM	H–1	CPV	FPV	PPV
VR0	90(90–91)91	0.3–0.8	3.5–5.7	0.4–1.8	0.4–1.1	0.7–1.8
VR0	92(none)94	0.6–1.2	0.6–1.1	1.3–1.9	1.0–1.6	2.1–2.7
VR1	159(159–162)162	2.0–7.3	1.4–2.4	1.8–3.5	2.5–3.4	1.6–3.8
VR2	227(227–230)230	0.8–3.1	2.1–3.5	1.7–1.8	0.6–3.0	1.5–2.2
VR2	232(232–233)235	0.3–2.8	0.5–1.2	2.0–3.0	1.9–3.2	0.4–1.2
VR2	237(none)241	0.3–1.0	0.2–0.7	1.8–3.2	1.7–3.1	2.0–5.0
VR3	296(296–297)298	0.7–2.7	0.5–0.8 *	1.4–3.3	1.7–3.8	2.2–4.1
VR3	302(none)303	0.1–0.2	0.4	1.5–4.5	1.5–4.5	3.2–5.7
VR4a	310(none)312	0.5–0.6	0.3–0.5	2.5–3.4	1.7–2.4	0.5–1.2
VR4a	320(320)322	0.5–2.8	1.0–1.9	2.3–2.8	1.7–2.4	1.3–3.9
VR5	359(none)367	0.3–1.2	0.2–1.6	2.0–6.8	0.9–6.0	0.6–1.6
VR5	370(none)371	0.4–1.2	0.4–0.6	3.5–3.7	0.1–1.0	0.8–1.0
VR6	386(390–391)392	0.7–4.7	0.6–3.2	2.7–4.6	0.9–4.5	1.3–3.5
VR4b	419(none)420	0.5–0.8	1.1–1.3	2.0–2.6	1.9–2.3	1.0–1.5
VR7	511(511)512	0.8–0.9	1.9–2.0	1.8–2.8	2.2	1.4–1.5
VR8	553(553–557)559	0.3–2.6	0.3–4.4	3.3–5.8	3.3–5.8	3.1–6.1
	Overall RMSD (LuIII) #	0.7	0.7	1	1	1
	% VP2 Identity (LuIII) $	73	70	53	52	52

RMSD = root mean squared deviation for Cα distances compared to LuIII for superposed protoparvovirus VP2 structures, the two highest RMSD values within each column are in bold; Residue Range = The range of LuIII residues within previously defined VRs. The VRs contain >2.0 Å Cα distances for 2 or more adjacent amino acids between superposed protoparvovirus structures; (parenthesis) = residues with Cα deviation >2.0 Å among the rodent protoparvoviruses, * indicates Cα distances of <2.0 Å in either H-1PV or MVM for residues within the parenthesis; ^# and ^$ = Overall RMSD and % identity compared to LuIII VP2, respectively.