Figure 6.

PAXX restricts production of infectious HSV-1 virions. WT or PAXX^−/− RPE-1 cells were infected with HSV-1 at MOI (A) 0.01, or (B) 4, and infectious virions were titrated onto vero cells to determine virus titre (plaque-forming units; PFU); (C) WT or Paxx^−/− MEFs were infected with HSV-1 at an MOI of 0.01, and infectious virions were titrated onto vero cells. Statistical significance, calculated by Student’s t-test, is denoted by stars—* = p < 0.05, *** = p < 0.01. n = 3. Error bars denote mean +/− SEM.