Table 2. Rate Constants of BlaC Inhibition with Clavulanic Acida.
approach | Ki (μM) | k2 (10–2 s–1) | k3 (10–4 s–1) | |
---|---|---|---|---|
NaPi pH 6.4 | fit to eqs 1 and 2 | 32 ± 2 | 2.9 ± 0.1 | 4 ± 1 |
simulation | 20 | 4.5 | 18 | |
MES pH 6.4 | fit to eqs 1 and 2 | 35 ± 4 | 4.9 ± 0.3 | 6 ± 3 |
simulation | 20 | 4.5 | 0.25 |
Errors represent the standard errors of the fit.