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. 2017 Oct 31;56(47):6257–6267. doi: 10.1021/acs.biochem.7b00556

Table 2. Rate Constants of BlaC Inhibition with Clavulanic Acida.

  approach Ki (μM) k2 (10–2 s–1) k3 (10–4 s–1)
NaPi pH 6.4 fit to eqs 1 and 2 32 ± 2 2.9 ± 0.1 4 ± 1
  simulation 20 4.5 18
MES pH 6.4 fit to eqs 1 and 2 35 ± 4 4.9 ± 0.3 6 ± 3
  simulation 20 4.5 0.25
a

Errors represent the standard errors of the fit.