Table 5.
Liver and plasma lipids after the six-week melatonin intervention.
| Group | C | D | L | M | H |
|---|---|---|---|---|---|
| Liver | |||||
| Triglyceride (mg/g tissue) | 18.5 ± 4.7 a | 16.4 ± 3.0 a | 10.4 ± 1.5 b | 10.0 ± 2.2 b | 9.3 ± 2.2 b |
| Cholesterol (mg/g tissue ) | 3.24 ± 0.96 a | 5.69 ± 0.98 b | 3.22 ± 0.75 a | 3.16 ± 0.51 a | 3.14 ± 0.70 a |
| Plasma | |||||
| Triglyceride (mg/dL) | 78.0 ± 15.4 a | 114.2 ± 15.0 b | 103.1 ± 19.7 b | 95.8 ± 14.6 a,b | 81.5 ± 18.8 a |
| Cholesterol (mg/dL) | 74.4 ± 12.5 a | 116.4 ± 12.5 c | 94.5 ± 17.8 b | 91.3 ± 12.3 b | 90.8 ± 10.7 b |
| HDL-C (mg/dL) | 38.0 ± 11.2 a | 39.2 ± 9.1 a | 39.0 ± 6.1 a | 45.8 ± 13.0 a | 59.6 ± 7.6 b |
| LDL-C (mg/dL) | 22.0 ± 9.9 a,b | 54.4 ± 10.7 c | 35.0± 17.5 b | 28.9 ± 9.6 b | 14.9 ± 6.2 a |
| Total Cholesterol/HDL-C ratio | 2.12 ± 0.55 a | 3.53 ± 0.67 b | 2.48 ± 0.65 a | 2.08 ± 0.29 a | 1.53 ± 0.18 c |
| LDL-C/HDL-C ratio | 0.67 ± 0.43 a,c | 1.83 ± 0.56 b | 0.93 ± 0.54 a | 0.64 ± 0.25 a,c | 0.25 ± 0.12 c |
All values are the mean ± SD (n = 8). a, b, c Values with different superscripts significantly differ between groups (p < 0.05). C, control group; D, diabetic group; L, low-dosage group (10 mg melatonin/kg of body weight (BW)); M, medium-dosage group (20 mg melatonin/kg of BW); H, high-dosage group (50 mg melatonin/kg of BW); HDL-C, high-density lipoprotein-cholesterol; and LDL-C, low-density lipoprotein-cholesterol.