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. 2017 Nov 14;9(11):1243. doi: 10.3390/nu9111243

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism of action of the phytochemical compounds of tucum-do-cerrado in the prevention of aging, by the upregulation SIRT1-Nrf2 pathway, attenuating oxidative stress and inflammation, in the liver. Tucum-do-cerrado is a source of phytochemical compounds, which might enter the cells and act directly as anti-inflammatory molecules and/or reducing agents, promoting the upregulation of the longevity protein SIRT1. The upregulation of SIRT1 may causes the deacetylation of Nrf2, making it stable and active. Nrf2 migrates to the nucleus and induces antioxidant enzymes and its own transcription, rising the cell antioxidant capacity. Then, by reduction of the ROS generation, the oxidative damages to protein and lipids are lowered and the inflammatory response is attenuated. The effect of tucum-do-cerrado in SIRT3 remains to be elucidated. Ac: acetylation; IL-6: interleukin-6; Keap1: Kelch-like ECH-associated protein 1; MDA: malondialdehyde; Nqo1: NAD(P)H dehydrogenase quinone 1; Nrf2: nuclear factor erythroid 2-related factor 2; ROS: reactive oxygen species; SIRT1: sirtuin 1; SIRT3: sirtuin 3; SOD: superoxide dismutase; TNF-α: tumor necrosis alpha.