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. 2017 Nov 29;37(48):11675–11687. doi: 10.1523/JNEUROSCI.3033-16.2017

Figure 4.

Figure 4.

Associations among white matter mean diffusivity, age group, fourth quartile stage 2 NREM fast sleep spindle density at CZ, and WML volume. A, Voxelwise comparison of the increase in white matter MD in older relative to young adults (in grayscale). B, Fourth quartile stage 2 NREM fast sleep spindle density at CZ predicting white matter MD while controlling for age group (in hot colors) overlaid on clusters demonstrating age effects (in grayscale). Effects are presented at p < 0.05 FWE whole-brain corrected at the cluster level. The mean extracted white matter MD across all significant voxels associated with fourth quartile stage 2 NREM fast sleep spindle density at CZ in young (red) and older (light blue) adults is presented below. C, Scatter plot of the association between fourth quartile stage 2 NREM fast sleep spindle density at CZ and mean extracted MD in young (red) and older (light blue) adults. D, Scatter plot of the association between white matter lesion (WML) volume and the mean extracted white matter MD across all significant voxels associated with fourth quartile stage 2 NREM fast sleep spindle density at CZ in older adults. ***p < 0.001.