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. 2017 Nov 29;37(48):11758–11768. doi: 10.1523/JNEUROSCI.1672-17.2017

Figure 1.

Figure 1.

MET-1 decreases excitability of DRG neurons. A, MET-1 (1:100 and 1:10) decreased the excitability of DRG neurons by increasing rheobase compared with media (N = 10 mice). B, MET-1 (1:100) increased the excitability of DRG neurons that innervate the colon, identified using the retrograde tracer fast blue (N = 3 mice). C, Superfusion of MET-1 (1:100) decreased spontaneous action potential discharge in single-unit extracellular recordings from the axons of colonic afferent neurons (N = 4 mice). D, The amplitude of intracellular [Ca2+] transients in response to capsaicin (2 μm), measured using fura-2 f340:380, was decreased in DRG neurons incubated in MET-1 (1:100) (N = 5 mice). *p < 0.05 (one-way ANOVA with Kruskal–Wallis test followed by Dunn's post hoc test). ***p < 0.001 (one-way ANOVA with Kruskal–Wallis test followed by Dunn's post hoc test). #p < 0.05 (unpaired t test). &p < 0.05 (paired t test).