Figure 6.

MET-1 decreases excitability of DRG neurons in an NFκB- and ERK1/2-dependent manner. A, MET-1 decreased excitability of DRG neurons by increasing rheobase compared with media; this effect was abolished following the addition of SC-514 (20 μm), an NFκB inhibitor (N = 4 mice). B, MET-1 decreased excitability of DRG neurons by increasing rheobase compared with media; this effect was abolished following the addition of PD98059 (30 μm) an ERK1/2 kinase inhibitor (N = 4 mice). ***p < 0.001 (one-way ANOVA with Newman–Keuls post hoc test). **p < 0.005; (one-way ANOVA with Newman–Keuls post hoc test).