Table 2.
Association analysis of rs13334190 in ZNF469 gene with keratoconus
| SNP (gene) | rs13334190 (ZNF469) | ||||
|---|---|---|---|---|---|
| Allelic analysis | Patients (n = 127) No. (%) |
Controls (n = 168) No. (%) |
Odds ratio | 95% confidence interval | p valuea (2-tailed) |
| G | 243 (0.956) | 313 (0.931) | 1 | Reference | – |
| Ab | 11 (0.043) | 23 (0.068) | 0.616 | 0.294–1.288 | 0.194 |
| HWE p | 0.61 | 0.79 | – | – | – |
| Genotype and model analysis | |||||
| G/G | 116 (91.3) | 146 (86.9) | 1 | Reference | – |
| G/A | 11 (8.6) | 21 (12.5) | 0.659 | 0.30–1.42 | 0.285 |
| A/A | 0 (0) | 1 (0.6) | – | – | – |
| Additive (trend) | – | – | – | – | 0.387 |
| Dominant | – | – | 0.629 | 0.29–1.35 | 0.232 |
aPearson Chi2 test
bRisk variant, HWE p Hardy–Weinberg equilibrium p value