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. 2016 Sep 15;1:16012. doi: 10.1038/npjvaccines.2016.12

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Copyright © 2016 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Vaccine-induced protection against chronic lung infection with M. tuberculosis. C57BL/6 mice (n=5) were vaccinated s.c. with 5×10⁵ CFU BCG or three times s.c. with 3 μg CysVac2. Twelve weeks after the first vaccination, the mice were challenged with approximately 100 CFU of M. tuberculosis by aerosol route and 20 weeks the frequency of Ag85B (a) or CysD (b) specific CD4⁺ T cells producing IFN-γ, IL-2 or TNF or IL-17 (c) was determined in lung cells stimulated ex vivo with each individual protein in the presence of brefeldin A. M. tuberculosis CFU in the lung at 20 weeks post-challenge (d). The data are presented as Log₁₀ of the mean of CFU±s.e.m. Data are representative of at least two independent experiments. The significance of differences between groups was determined by one- or two-way analysis of variance (ANOVA) (ns=not significant; *P<0.05; **P<0.01).