Table 1.

Differences in gene expression of high (n = 5) and low (n = 4) responder cows, as determined by a normal t-test

Time point
Genes	C. diff. 6 ha	C. diff. 24 ha	C. diff. 72 ha
	Low vs. Highb	Low vs. Highb	Low vs. Highb
TLR pathway
LY96		***	**
CD14	+	***	*
MYD88		+
TIRAP	*	**	***
TRAF6		+
IRAK4		*
IRAK1		+
RELA		**
Chemokines
CCL5	+	*
CXCL5	+
CXCL8	+		+
IL13RA		*	+
Inflammatory cytokines
IL1-A			+
IL6	**	+	*
Acute phase proteins/danger associated molecular pattern molecules
S100A9			*
S100A12			*
Antimicrobial peptides
LYZ1			**
LPO			*
Apoptosis
FAS	*	**	*
TNFRSF1A		+
CASP8		**	+
CASP3	*	*
BAX		**
BCL-2	+		*
Scavenger Receptor
CD68	**	*
CD40	**	**	*
JAK-STAT signaling
STAT2		**
MAPK signaling
MAPK 8	**	*
Others
MMP1		*	**
MX2		+
NOD2			*
AKT1		*
WNT4			+

^aTreatment time with C. diff. in hours

^blow responder animals versus high responder animals

*p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001

+distinct changes (0.01 ≤ p < 0.05)