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. 2017 Nov 29;11:116. doi: 10.1186/s12918-017-0485-2

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Known motifs cannot explain loss of expression after 60 LE. For each sequence, the binding structure structure is shown (left). Height of bars is proportional to LLR of binding for each motif. A subset of motifs are shown. Binding sites for all factors considered in this work are included in Additional file 1: Figures S5-S15. We also show FISH for lacZ driven by each of the sequences (right). a e60. b e72. This sequence is only 12 bp different than e60. c e72 with the affinity for a Hb site (arrow) restored to levels in e60. The construct does not drive expression. d e72 with the affinity for a Hb site and Bcd motif (arrows) restored to levels in e60. The construct does not drive expression. e e72 with the a Cic motif (arrow) removed, as in e60. The construct does not drive expression