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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Cancer Res. 2017 Sep 15;77(22):6109–6118. doi: 10.1158/0008-5472.CAN-17-1262

Figure 5. Mouse angiosarcomas gene expression consistent with human angiosarcoma.

Figure 5

(A) Principle component analysis (PCA) of samples from human (sphere) and mouse (polyhedron) tissue; angiosarcomas (red), coronary artery (yellow) and aorta (blue). (B) Dendogram of panel of soft tissue sarcomas including human angiosarcoma and ADFlox/− mouse angiosarcomas showing ranked correlation clustering. Spearman correlation between mouse and human angiosarcoma = 0.75. (C) Ranked-correlation matrix among 12,993 ortholog gene pairs in ADFlox/− mouse angiosarcomas and panel of human soft tissue sarcomas. Spearman correlation coefficients shown for each comparison. (D) APLN and APLNR expression in human angiosarcoma (n = 7) compared to human normal aorta (GSE26155, n = 13) from deposited microarray analysis expressed as Log2 signal intensity. P value = 0.067 for APLN and P value < 0.001 for APLNR.