Fig. 1.

JMJD6 Is Up-regulated in Melanoma, and High Expression of JMJD6 Is Correlated with Melanoma Aggressiveness. a JMJD6 mRNA expression levels in multiple cancers by online analysis (www.cbioportal.org/public-portal/). b Representative sections of normal, primary melanomas and metastatic melanomas that were stained with JMJD6 antibody are presented (Upper magnification: × 20; scale bar = 100 μm. Lower magnification: × 320; scale bar = 25 μm). The scores were determined by evaluating the intensity and extent of immunopositivity. The results were analyzed by two-tailed unpaired t-tests (*p < 0.05). c Representative sections of clinicopathologic stages I, II, III and IV of melanoma that were stained with JMJD6 antibody are presented (Upper magnification: × 20; scale bar = 100 μm. Lower magnification: × 320; scale bar = 25 μm). The scores were determined by evaluating the intensity and extent of immunopositivity. The results were analyzed by two-tailed unpaired t-tests (*p < 0.05). d The survival rate of melanoma patients with high or low JMJD6 expression was analyzed by the Mantel-Cox log-rank test (*p < 0.05) (http://bioinformatica.mty.itesm.mx:8080/Biomatec/SurvivaX.jsp)