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. 2017 Nov 27;12:8443–8457. doi: 10.2147/IJN.S146866

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© 2017 Wang et al. This work is published and licensed by Dove Medical Press Limited

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317L-Cu stainless steel significantly increased the Cu²⁺ content in the callus and further enhanced the expression of Runx2 in the fracture local site.

Notes: (A) Significant increase in Cu²⁺ content in the calluses of the 317L-Cu SS group compared with that of the control group at 3, 6, and 9 weeks. (B) Runx2 expression in the 317L-Cu SS group is significantly higher than that in the 317L SS group at 3 and 6 weeks. (C) 317L-Cu SS could not increase the concentration of serum Cu²⁺. *P<0.05; **P<0.01.

Abbreviations: GAPDH, glyceraldehyde-3-phosphate dehydrogenase; W, weeks.