Table 2.

Neuronal numbers found in selected structures through detailed quantitative histopathological analyses, performed by researchers from the NSWTRC

Measurement	N	AE	AE + WE	AE + WE + KS
Cortical neurons (superior frontal)55	100	77	80	84
Cortical neurons (dendritic arbor)56	100	81	75	70
Hippocampal neurons55	100	100	100	100
Thalamus (mediodorsal)57	100	100	52	36
Thalamus (anterior)57	100	100	86	47
Mamillary bodies57	100	98	53	32
Basal forebrain58	100	100	76	79
Locus ceruleus59	100	100	100	100
Median raphe60	100	95	30	30
Dorsal raphe61	100	98	36	36
Cerebellar vermis (purkinje cells)54	100	95	57	57

Notes: Percentages indicate variance from control data. A change of color (from left to right) indicates a statistically significant difference. Reprinted from http://www.ProgNeuro-PsychopharmacologyBiolPsychiatry, 2003;27(6), Harper C, Dixon G, Sheedy D, Garrick T. Neuropathological alterations in alcoholic brains. Studies arising from the New South Wales Tissue Resource Centre. 951–961. Copyright © 2003, with permission from Elsevier.²⁶

Abbreviations: N, normal controls; AE, alcoholic encephalopathy; WE, Wernicke encephalopathy; KS, Korsakoff’s syndrome; NSWTRC, New South Wales Tissue Resource Centre.