. 2017 Nov 28;4(2):e000635. doi: 10.1136/openhrt-2017-000635

Table 3.

Analysis of variance (ANOVA) results for all inflammatory markers in the heart transplant recipients

Variables† n=14 HTx		Baseline‡	15 min	30 min	1 hour	2 hours	Time	Group	Time×group
General inflammation
CRP§	MICT	3.40±1.10	2.85±0.80	2.74±0.78	2.47±0.61	2.93±0.69	0.601	0.362	0.422
CRP§	HIT	3.40±1.10	4.10±0.96	3.9±0.94	3.58±0.88	3.46±0.83	0.601	0.362	0.422
sTNFr1¶	MICT	3.08±0.25	3.17±0.16	3.39±0.20	3.09±0.21	2.91±0.17	<0.001**	0.616	0.112
sTNFr1¶	HIT	3.08±0.25	3.38±0.24	3.56±0.20	2.76±0.16	2.74±0.18	<0.001**	0.616	0.112
Vascular inflammation
vWF††	MICT	191±31	117±17	131±20	138±23	173±28	0.175	0.044	0.075*
vWF††	HIT	191±31	179±29	239±48	151±26	151±23	0.175	0.044	0.075*
VCAM	MICT	511±36	527±36	486±29	458±29	468±26	0.069	0.672	0.422
VCAM	HIT	511±36	495±23	507±32	446±20	460±25	0.069	0.672	0.422
Blood platelets
PDGF	MICT	2.08±0.22	2.48±0.33	2.72±0.33	2.22±0.28	2.17±0.21	0.002**	0.162	0.690
PDGF	HIT	2.08±0.22	2.78±0.40	3.00±0.43	2.33±0.24	2.33±0.30	0.002**	0.162	0.690
sCD40L	MICT	1.07±0.15	1.29±0.18	1.26±0.18	1.04±0.15	1.06±0.17	<0.001**	0.047	0.237
sCD40L	HIT	1.07±0.15	1.41±0.20	1.46±0.21	1.20±0.18	1.14±0.16	<0.001**	0.047	0.237
DKK-1	MICT	2.85±0.62	3.15±0.84	3.49±0.87	3.00±0.69	2.80±0.71	0.023**	0.995	0.130
DKK-1	HIT	2.85±0.62	3.42±0.86	4.13±0.83	2.15±0.49	2.74±0.44	0.023**	0.995	0.130
Angiogenesis
VEGF-1¶	MICT	0.24±0.03	0.26±0.04	0.26±0.04	0.24±0.03	0.26±0.03	0.020**	0.275	0.077*
VEGF-1¶	HIT	0.24±0.03	0.29±0.04	0.29±0.04	0.24±0.03	0.24±0.03	0.020**	0.275	0.077*
Ang-2¶	MICT	1.60±0.20	1.97±0.26	2.06±0.22	1.74±0.20	1.75±0.21	<0.001**	0.415	0.095*
Ang-2¶	HIT	1.60±0.20	1.97±0.26	2.06±0.22	1.75±0.20	1.64±0.21	<0.001**	0.415	0.095*
Tie-2	MICT	15.8±1.3	15.2±1.7	15.2±1.4	16.5±1.5	15.9±1.2	0.632	0.362	0.250
Tie-2	HIT	15.8±1.3	16.2±1.6	16.3±1.6	16.3±1.5	15.4±1.7	0.632	0.362	0.250
Endostatin	MICT	165±11	166±12	169±12	163±9	159±11	0.206	0.167	0.594
Endostatin	HIT	165±11	184±14	183±13	170±13	162±12	0.206	0.167	0.594
Cardiokine/myokine
GDF-15	MICT	1.03±0.11	1.20±0.19	1.19±0.19	1.12±0.19	1.10±0.19	0.206	0.041	0.067*
GDF-15	HIT	1.03±0.11	1.10±0.11	1.15±0.11	0.96±0.11	0.93±0.08	0.206	0.041	0.067*
ST2	MICT	20.3±2.0	20.0±1.9	20.5±2.1	20.1±1.8	20.7±2.2	0.425	0.112	0.228
ST2	HIT	20.3±2.0	22.4±2.2	22.7±2.2	21.2±2.0	21.3±2.4	0.425	0.112	0.228
SPARC	MICT	319±57	486±60	433±95	297±64	294±63	0.020**	0.122	0.745
SPARC	HIT	319±57	391±79	491±84	336±60	328±56	0.020**	0.122	0.745

*P value <0.10.

**Significant P values <0.05.

†All variables are measured in ng/mL serum if not otherwise stated.

‡Results from 1 week ahead of first exercise session.

§Measured as μg/mL.

¶Analysis of variance was performed with log-transformed variables.

††Measured as per cent of pool.

Ang-2, angiopoietin-2; CRP, C reactive protein; DKK-1, Dickkopf-related protein 1; GDF-15, growth differentiation factor-15; HIT, high-intensity interval training; HTx, heart transplant recipients; MICT, moderate-intensity continuous training; PDGF, platelet-derived growth factor; sCD40L, soluble CD40 ligand; SPARC, secreted protein acidic and rich in cysteine; ST2, interleukin 1 receptor-like 1; sTNF1, soluble tumour necrosis factor receptor 1; Tie-2, tyrosine kinase with immunoglobulin-like and EGF-like domains 2; VCAM, vascular cell adhesion molecule; VEGF-1, vascular endothelial growth factor-1; vWF, von Willebrand factor.