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. 2017 Oct 25;7(78):49586–49599. doi: 10.1039/c7ra09076e

Table 2. Radiochemical yields (±standard deviation) for the reactions of 68Ga3+ with DOTA, NOTA, NOTP, TRAP, HBED, DFO and THP. Experiments were undertaken in triplicate.

Chelator Concentration (μM) pH 3.5, 25 °C pH 3.5, 90 °C pH 6.5, 25 °C pH 6.5, 90 °C
DOTA 500 98.3 ± 0.4 97.0 ± 0.7
50 86.7 ± 5.0 95.3 ± 0.9 73.2 ± 6.4 97.2 ± 0.3
5 20.7 ± 5.6 90.1 ± 1.5 9.6 ± 5.9 21.6 ± 2.5
0.5 6.2 ± 2.8 16.5 ± 2.2 2.3 ± 0.7 2.8 ± 0.2
0.05 3.5 ± 1.1 3.1 ± 0.7 1.7 ± 0.5 2.8 ± 0.5
NOTA 500 98.2 ± 0.6 96.6 ± 1.2
50 96.2 ± 1.7 93.7 ± 0.3 97.5 ± 0.1 98.5 ± 0.1
5 93.2 ± 2.0 57.3 ± 2.6 90.6 ± 4.5 94.4 ± 0.4
0.5 25.4 ± 35.6 17.4 ± 2.1 3.8 ± 0.3 4.9 ± 0.4
0.05 4.0 ± 2.2 2.2 ± 0.5 1.9 ± 0.7 2.8 ± 0.2
NOTP 500 97.0 ± 0.8 96.7 ± 1.8
50 95.0 ± 1.8 54.3 ± 2.4 97.5 ± 0.1 97.3 ± 0.4
5 68.7 ± 25.0 74.9 ± 3.4 96.6 ± 0.4 94.2 ± 0.9
0.5 26.8 ± 33.0 20.0 ± 1.9 84.3 ± 0.9 93.5 ± 0.8
0.05 5.2 ± 3.7 3.9 ± 0.7 4.8 ± 0.4 6.8 ± 1.2
TRAP 500 95.6 ± 0.7 96.5 ± 0.4
50 95.0 ± 1.3 93.0 ± 0.6 96.6 ± 0.1 96.0 ± 1.4
5 92.5 ± 2.4 92.0 ± 1.5 89.0 ± 1.4 95.2 ± 0.4
0.5 23.0 ± 9.5 53.1 ± 4.8 5.1 ± 0.8 8.8 ± 2.0
0.05 7.4 ± 1.5 5.5 ± 0.6 2.0 ± 0.5 2.8 ± 0.5
HBED 500 93.2 ± 3.8 92.2 ± 0.6
50 90.4 ± 8.1 87.7 ± 0.5 93.3 ± 3.0 97.2 ± 0.4
5 68.6 ± 23.5 75.2 ± 0.8 92.7 ± 2.2 95.4 ± 0.8
0.5 11.6 ± 11.9 5.8 ± 0.4 86.0 ± 3.9 87.5 ± 4.4
0.05 4.9 ± 2.2 2.5 ± 0.4 4.6 ± 0.7 5.1 ± 0.8
DFO 500 96.0 ± 0.8 96.4 ± 1.4
50 24.5 ± 1.9 97.5 ± 0.7
5 23.0 ± 12.9 97.0 ± 1.0
0.5 10.5 ± 5.4 95.8 ± 1.5
0.05 11.2 ± 5.0 3.6 ± 1.3
THP 500 96.7 ± 1.4 96.2 ± 0.8 95.8 ± 1.6 94.3 ± 0.7
50 92.7 ± 4.2 95.9 ± 0.5 97.1 ± 1.1 94.2 ± 0.6
5 77.8 ± 13.5 92.7 ± 1.1 97.1 ± 0.1 94.0 ± 0.3
0.5 25.4 ± 6.8 83.4 ± 1.1 97.1 ± 0.6 10.7 ± 2.6
0.05 14.0 ± 6.8 24.3 ± 3.4 3.8 ± 3.6 6.1 ± 1.1