Table 2. Radiochemical yields (±standard deviation) for the reactions of 68Ga3+ with DOTA, NOTA, NOTP, TRAP, HBED, DFO and THP. Experiments were undertaken in triplicate.
Chelator | Concentration (μM) | pH 3.5, 25 °C | pH 3.5, 90 °C | pH 6.5, 25 °C | pH 6.5, 90 °C |
DOTA | 500 | 98.3 ± 0.4 | 97.0 ± 0.7 | ||
50 | 86.7 ± 5.0 | 95.3 ± 0.9 | 73.2 ± 6.4 | 97.2 ± 0.3 | |
5 | 20.7 ± 5.6 | 90.1 ± 1.5 | 9.6 ± 5.9 | 21.6 ± 2.5 | |
0.5 | 6.2 ± 2.8 | 16.5 ± 2.2 | 2.3 ± 0.7 | 2.8 ± 0.2 | |
0.05 | 3.5 ± 1.1 | 3.1 ± 0.7 | 1.7 ± 0.5 | 2.8 ± 0.5 | |
NOTA | 500 | 98.2 ± 0.6 | 96.6 ± 1.2 | ||
50 | 96.2 ± 1.7 | 93.7 ± 0.3 | 97.5 ± 0.1 | 98.5 ± 0.1 | |
5 | 93.2 ± 2.0 | 57.3 ± 2.6 | 90.6 ± 4.5 | 94.4 ± 0.4 | |
0.5 | 25.4 ± 35.6 | 17.4 ± 2.1 | 3.8 ± 0.3 | 4.9 ± 0.4 | |
0.05 | 4.0 ± 2.2 | 2.2 ± 0.5 | 1.9 ± 0.7 | 2.8 ± 0.2 | |
NOTP | 500 | 97.0 ± 0.8 | 96.7 ± 1.8 | ||
50 | 95.0 ± 1.8 | 54.3 ± 2.4 | 97.5 ± 0.1 | 97.3 ± 0.4 | |
5 | 68.7 ± 25.0 | 74.9 ± 3.4 | 96.6 ± 0.4 | 94.2 ± 0.9 | |
0.5 | 26.8 ± 33.0 | 20.0 ± 1.9 | 84.3 ± 0.9 | 93.5 ± 0.8 | |
0.05 | 5.2 ± 3.7 | 3.9 ± 0.7 | 4.8 ± 0.4 | 6.8 ± 1.2 | |
TRAP | 500 | 95.6 ± 0.7 | 96.5 ± 0.4 | ||
50 | 95.0 ± 1.3 | 93.0 ± 0.6 | 96.6 ± 0.1 | 96.0 ± 1.4 | |
5 | 92.5 ± 2.4 | 92.0 ± 1.5 | 89.0 ± 1.4 | 95.2 ± 0.4 | |
0.5 | 23.0 ± 9.5 | 53.1 ± 4.8 | 5.1 ± 0.8 | 8.8 ± 2.0 | |
0.05 | 7.4 ± 1.5 | 5.5 ± 0.6 | 2.0 ± 0.5 | 2.8 ± 0.5 | |
HBED | 500 | 93.2 ± 3.8 | 92.2 ± 0.6 | ||
50 | 90.4 ± 8.1 | 87.7 ± 0.5 | 93.3 ± 3.0 | 97.2 ± 0.4 | |
5 | 68.6 ± 23.5 | 75.2 ± 0.8 | 92.7 ± 2.2 | 95.4 ± 0.8 | |
0.5 | 11.6 ± 11.9 | 5.8 ± 0.4 | 86.0 ± 3.9 | 87.5 ± 4.4 | |
0.05 | 4.9 ± 2.2 | 2.5 ± 0.4 | 4.6 ± 0.7 | 5.1 ± 0.8 | |
DFO | 500 | 96.0 ± 0.8 | 96.4 ± 1.4 | ||
50 | 24.5 ± 1.9 | 97.5 ± 0.7 | |||
5 | 23.0 ± 12.9 | 97.0 ± 1.0 | |||
0.5 | 10.5 ± 5.4 | 95.8 ± 1.5 | |||
0.05 | 11.2 ± 5.0 | 3.6 ± 1.3 | |||
THP | 500 | 96.7 ± 1.4 | 96.2 ± 0.8 | 95.8 ± 1.6 | 94.3 ± 0.7 |
50 | 92.7 ± 4.2 | 95.9 ± 0.5 | 97.1 ± 1.1 | 94.2 ± 0.6 | |
5 | 77.8 ± 13.5 | 92.7 ± 1.1 | 97.1 ± 0.1 | 94.0 ± 0.3 | |
0.5 | 25.4 ± 6.8 | 83.4 ± 1.1 | 97.1 ± 0.6 | 10.7 ± 2.6 | |
0.05 | 14.0 ± 6.8 | 24.3 ± 3.4 | 3.8 ± 3.6 | 6.1 ± 1.1 |