Relationship between WA% and extent of emphysema (LAA%) in 94 COPD patients and 20 asymptomatic smokers. Horizontal line shows the mean +2SD of LAA% of the asymptomatic smokers. Vertical line shows the mean +2SD of WA% of the asymptomatic smokers. Using these cutoff values, COPD patients can be divided into groups; airway remodeling-dominant group (high WA% and low LAA%), emphysema-dominant group (low WA% and high LAA%), and a mixed group (high WA% and high LAA%). Reproduced with permission from reference (96). WA, wall area; LAA, low attenuation areas; COPD, chronic obstructive pulmonary diseases.