Table 4. Studies registered at ClinicalTrials.gov that includes quantitative CT features (density, volume, texture analysis) of the lung. Accessed on March 24, 2017.
| ClinicalTrials.gov Identifier | Title | Status | Sponsor |
|---|---|---|---|
| COPD | |||
| NCT02599883 | Evidence-based analysis of low-dose CT in management of COPD | Completed | Azienda Ospedaliero-Universitaria di Parma, Italy |
| NCT01192932 | Effects of nycthemeral variations on CT Parameters Reflecting Airways remodelling, and pulmonary emphysema extent in COPD | Completed | Erasme University Hospital, Belgium |
| NCT01142531 | Effects of bronchodilation on CT parameters reflecting airways remodelling, and pulmonary emphysema extent | Completed | Erasme University Hospital, Belgium |
| NCT00232674 | Efficacy study of the effect of budesonide on emphysema | Completed | AstraZeneca, UK |
| NCT01431625 | Effects of exercise training on systemic inflammation an muscle repair according to the COPD phenotype | Unknown | Hospitales Universitarios Virgen del Rocío, Spain |
| NCT02245178 | Lung function decline and disease risk from young adulthood to middle age (CARDIA Lung) | Enrolling by invitation | Northwestern University, USA |
| NCT00874497 | Pilot study of tetomilast in COPD associated with emphysema (EMPHASIS) | Terminated | Otsuka Pharmaceutical Development & Commercialization, Inc. USA |
| NCT01869205 | The effect and mechanism of bronchoscopic lung volume reduction by endobronchial valve in Korean emphysema patients | Unknown | Asan Medical Center, South Korea |
| NCT00720226 | Efficacy of losartan in preventing progression of COPD | Unknown | John Hopkins University, USA |
| NCT00180622 | Markers for COPD | Completed | Imperial College London, UK |
| NCT00608764 | Examining the genetic factors that may cause COPD (COPD Gene) | Recruiting participants | Brigham and Women's Hospital, USA |
| NCT02826265 | Evaluation of novel lung function parameters and quantitative computed tomography (qCT) in patients with pulmonary disease | Recruiting participants | Universitätsmedizin Mannheim, Germany |
| NCT02238327 | Longitudinal evaluation of HIV-associated Lung disease phenotypes (LEAP) | Recruiting participants | University of Pittsburgh, USA |
| NCT03002389 | Hyperpolarized xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeutics | Recruiting participants | University of Virginia, USA |
| NCT01969344 | Study of COPD subgroups and biomarkers (SPIROMICS) | Active, not recruiting | University of North Carolina, Chapel Hill, USA |
| NCT03026439 | Searching COPD onset (SOON) | Recruiting participants | Pontificia Universidad Catolica de Chile, Chile |
| NCT02879773 | CT assessment of regional ventilation (CURVE) | Recruiting participants | Heart of England NHS Trust, UK |
| NCT00475007 | Clinical trial to evaluate the safety and effectiveness of the IBV® valve system for the treatment of severe emphysema (IBV®Valve) | Completed | Spiration Inc. USA |
| NCT02627872 | Clinical & systems medicine investigations of smoking-related chronic obstructive pulmonary disease (COSMIC) | Active, not recruiting | Karolinska Institutet, Sweden |
| NCT03049202 | Bronchoalveolar investigations of never-smokers with chronic obstruction from the swedish cardio pulmonary bioimage study (BRONCOSCAPIS) | Recruiting participants | Karolinska Institutet, Sweden |
| NCT02719184 | Longitudinal follow up to assess biomarkers predictive of emphysema progression in patients with COPD | Recruiting participants | Boehringer Ingelheim, Germany |
| NCT01693003 | Indacaterol versus Tiotropium on dynamic hyperinflation in COPD | Completed | Irmandade Santa Casa de Misericórdia de Porto Alegre, Brasil |
| NCT02451540 | Evaluation of the effect of Roflumilast in hyperinflated COPD patients using functional respiratory imaging | Recruiting participants | FLUIDDA nv, Belgium |
| NCT02523833 | Small airway involvement in patients with chronic hypersensitivity pneumonitis | Recruiting participants | University of Sao Paulo General Hospital, Brasil |
| NCT01983241 | Efficacy and safety of alpha1-proteinase inhibitor (human), modified process (alpha-1 MP) in subjects with pulmonary emphysema due to alpha1 antitrypsin deficiency (AATD) (SPARTA) | Recruiting participants | Grifols Therapeutics Inc., USA |
| Fibrosis | |||
| NCT02267655 | Three part study to assess inhaled nitric oxide on functional pulmonary imaging in subjects with pulmonary hypertension associated with COPD and IPF | Recruiting participants | Bellerophon, USA |
| NCT03068091 | Assessment of lung movement with CT | Recruiting participants | University of Missouri-Columbia, USA |
| NCT02550873 | A Trial to evaluate the efficacy of PRM-151 in subjects with idiopathic pulmonary fibrosis (IPF) | Active not recruiting | Promedior, Inc. USA |
| NCT02523833 | Small airway involvement in patients with chronic hypersensitivity pneumonitis | Recruiting participants | University of Sao Paulo General Hospital, Brazil |
| NCT02596841 | Lung diffusing capacity for nitric oxide as a marker of fibrotic changes in idiopathic interstitial pneumonias (Dm & Vc) | Completed | IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy |
| NCT01200888 | Controlled ventilation CT in CF infants | Unknown | Stanford University, USA |
| NCT02488304 | Prospective study for transplant optimization using functional imaging (TROFI) | Recruiting participants | FLUIDDA nv, Belgium |
| NCT02441413 | Transplant optimization using functional imaging (TROFI) (TROFI_BE) | Active not recruiting | FLUIDDA nv, Belgium |
| NCT02745145 | Abituzumab in SSc-ILD | Recruiting participants | EMD Serono Research & Development Institute, Inc. USA |
COPD, chronic obstructive pulmonary diseases; CT, computed tomography.