Table 3. Univariate and multivariate analysis of baseline factors that predict 60-day mortality*.
| Variable | Unadjusted OR (95% CI) | P | Adjusted OR† (95% CI) | P |
|---|---|---|---|---|
| Age | 1.04 (0.99–1.09) | 0.12 | 1.06 (0.998–1.12) | 0.06 |
| Male sex | 1.11 (0.35–3.50) | 0.86 | ||
| BMI | 0.95 (0.80–1.13) | 0.56 | ||
| Solid cancer‡ | 4.57 (0.75–27.93) | 0.10 | ||
| Before HFNC | ||||
| Mean arterial pressure | 0.97 (0.92–1.01) | 0.17 | ||
| Heart rate | 1.03 (0.99–1.06) | 0.17 | ||
| P(A-a)O2 | 1.01 (0.999–1.01) | 0.07 | ||
| Serum bicarbonate | 0.87 (0.75–1.002) | 0.054 | ||
| C-reactive protein | 1.03 (0.96–1.11) | 0.39 | ||
| SOFA score | 1.59 (1.09–2.32) | 0.02 | 1.48 (0.94–2.32) | 0.09 |
| Cytomegalovirus co-infection | 2.95 (0.58–14.99) | 0.19 | ||
| HFNC failure | 7.14 (1.74–29.41) | 0.006 | 6.92 (1.24–38.62) | 0.03 |
*, Discrimination (AUC =0.83) and calibration (Hosmer and Lemeshow χ2 =14.56; P=0.07). †, Variables with P values <0.20 in the univariate analysis were included in the multivariate analysis by using stepwise backward selection procedures; ‡, solid cancer was excluded for multivariate analysis due to multicollinearity with HFNC failure. OR, odds ratio; BMI, body mass index; HFNC, high flow nasal cannula; P(A-a)O2, alveolar-arterial PO2 difference; SOFA, Sequential Organ Failure Assessment.